You do not need to believe in QWERTY tales or have an appendicitis to realize that evolution - natural or social - is suboptimal. Just look at this amazing history of the alphabet (via Alex). There are lots of problems with similar letters: V and U; lowercase L and 1; and J and I. Besides, some are rather ugly. (I can't stand the letter "R" and "K").
The guys from Stumbling and Mumbling raised the same point: English (or any language) is obviously inefficient and a result of lock-in mechanisms. But, please, do not search for a solution.